Trimix requires next to zero outside stimulation. Applied directly to the base of the penis (Take a look at the Trimix Instructional Video), results will generally occur within 10 minutes. Depending on the patient’s requested strength a trimix injection can last anywhere from 20 minutes to 2 plus hours. Trimix is a mixture of three compounded medications; Alprostadil, Papaverine, Phentolamine. For those that have had minimal success or experienced uncomfortable side effects with oral ED meds it is a highly effective alternative. Unlike oral ED meds, it is safe for patients on nitrates and alpha blockers.